In today's oral presentation (Abstract #4979), "Development of KITE-585: A fully human anti-BCMA CAR T-cell therapy for the treatment of multiple myeloma," KITE-585 demonstrated potent in vitro and in vivo activity against MM cell lines. CAR T cells were active in the presence of soluble BCMA and also eradicated established MM tumors in mice. KITE-585 contains a proprietary linker with the CD28 costimulatory domain. This configuration resulted in polyfunctional activation and proliferation of T-cells in the presence of MM cell lines, with no evidence of tonic signaling in the absence of target cells.
In the poster presentation (Abstract #2135), "Selectivity and specificity of engineered T cells expressing KITE-585, a chimeric antigen receptor targeting B-cell maturation antigen (BCMA)," the selectivity of KITE-585's novel single-chain variable fragment (scFv) for BCMA was assessed using Retrogenix™ cell microarray technology. The results demonstrated the specificity of KITE-585 for BCMA expressing target cells.
"These promising preclinical data presented at AACR suggest the
potential of KITE-585 to offer a one-time treatment to address the high
unmet need in multiple myeloma, an incurable blood cancer," said
About Multiple Myeloma
Multiple myeloma (MM) is a rare and aggressive cancer. In 2016, there
were an estimated 30,330 new cases of MM and 12,650 disease-related
deaths in the
KITE-585 is an investigational therapy in which a patient's T cells are engineered to express a chimeric antigen receptor (CAR) to target the B cell maturation antigen (BCMA), a protein expressed on the cell surface of multiple myelomas (MM), and redirect the T cells to kill cancer cells. Kite expects to file an investigational new drug application (IND) for KITE-585 and initiate a Phase 1 clinical trial of KITE-585 in 2017.
Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit www.kitepharma.com. Sign up to follow @KitePharma on Twitter at www.twitter.com/kitepharma.
Cautionary Note on Forward-Looking Statements
This press release contains forward-looking statements for purposes of
the safe harbor provisions of the Private Securities Litigation Reform
Act of 1995. The press release may, in some cases, use terms such as
"predicts," "believes," "potential," "proposed," "continue,"
"estimates," "anticipates," "expects," "plans," "intends," "may,"
"could," "might," "will," "should" or other words that convey
uncertainty of future events or outcomes to identify these
forward-looking statements. Forward-looking statements include
statements regarding intentions, beliefs, projections, outlook, analyses
or current expectations concerning, among other things: the expectations
for KITE-585 to offer a one-time treatment to address multiple myeloma,
and the timing and ability to file an IND and initiate a clinical trial
of KITE-585 in 2017. Various factors may cause differences between
Kite's expectations and actual results as discussed in greater detail in
Kite's filings with the
3 NCCN and Rajkumar,
4 Rajkumar, S. V. (2012), Multiple myeloma: 2012 update on diagnosis, risk-stratification, and management. Am. J. Hematol., 87: 78-88. doi:10.1002/ajh.22237.
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