"KITE-585 has the potential to become Kite's next significant advance in
cell therapy for patients with cancer. It is the result of an extensive
preclinical development effort that included candidate screening,
engineering, and testing by Kite's internal research team and it
reflects the company's deep experience in CAR design and cellular
BCMA is expressed on the surface of malignant plasma cells in most patients with multiple myeloma. In addition, it is found on normal plasma cells and certain mature B-cell lineage cells but is absent from other tissues. Because BCMA has been shown to play a potential role in survival and growth of myeloma cells, it is viewed as an attractive CAR T-cell therapeutic target.
KITE-585 is an anti-BCMA CAR construct designed for high binding affinity to BCMA expressed on the cell surface. KITE-585 contains a receptor derived from a fully human monoclonal antibody and a CD28 costimulatory domain intended for optimized T-cell expansion and function. In preclinical studies, KITE-585 demonstrated activity across a range of low and high BCMA expressing targets and its activity was not impaired by soluble BCMA. In the presence of cell-bound BCMA, KITE-585 induced polyfunctional T cell expansion, and no tonic signaling in its absence. Advanced processes and materials used in the manufacturing of KITE-585 are designed to achieve enhanced cell potency.
About Multiple Myeloma
Multiple myeloma is a cancer of plasma cells in the bone marrow, which
make antibodies to fight infections. Abnormal plasma cells can grow out
of control and suppress the growth of other cells in the bone marrow.
This suppression may result in bone damage, anemia, excessive bleeding,
and a decreased ability to fight infection. In 2017, there will be an
estimated 30,280 new cases of multiple myeloma in
Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit www.kitepharma.com. Sign up to follow @KitePharma on Twitter at www.twitter.com/kitepharma.
Cautionary Note on Forward-Looking Statements
This press release contains forward-looking statements for purposes of
the safe harbor provisions of the Private Securities Litigation Reform
Act of 1995. The press release may, in some cases, use terms such as
"predicts," "believes," "potential," "proposed," "continue,"
"estimates," "anticipates," "expects," "plans," "intends," "may,"
"could," "might," "will," "should" or other words that convey
uncertainty of future events or outcomes to identify these
forward-looking statements. Forward-looking statements include
statements regarding intentions, beliefs, projections, outlook, analyses
or current expectations concerning, among other things: the ability to
advance and the success of KITE-585, the ability to rapidly execute the
KITE-585 clinical program, and the ability of Kite's manufacturing
process and materials to enhance product potency and activity. Various
factors may cause differences between Kite's expectations and actual
results as discussed in greater detail in Kite's filings with the
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